BACKGROUND: Dermatomyositis (DM) is a rare inflammatory musculocutaneous disease of presumed autoimmune origin. OBJECTIVE: The purpose of our study was to analyze the clinical manifestations of DM, METHODS: A retrospective study of 18 patients with DM is analyzed. RESULTS: 1. The range of age was from 3 to 72 years, and the most frequent age group was 46-60 (38.9%). Male to female ratio was 1:8. 2. Among the 18 patients, 61.1% was classified as DM, 38.9% as amyopathic dermatomyositis (ADM), 3. Skin rash was noted 100%, itching 72.2%, proximal muscle weakness 61.1%, myalgia 38.2%, arthralgia 22.2%, hair loss 22.2%, Raynaud's phenomenon 22.2%. Arnong the skin rash, Gottron's sign was most frequent (83.3%), followed by heliotrope rash (72.2%), Gottron's papule (66.6%). 4. Serum CPK level was elevated in 38.9%, LDH 88.9%, SGOT 44.4%, SGPT 33.3%, and ESR 61.1%. 5. DM patients were treated with prednisolone 400mg/kg/day and hydroxychloroquine 400mg/day (childhood 5mg/kg/day) for 4~8 weeks. Four patients who had severe skin manifestations and pruritus added methotrexate. Four ADM patients were treated with hydroxychloroquine 5mg/kg/day only. Two ADM patients were added prednisolone 1mg/kg/day for 6 weeks.
Affiliation:
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. jhchung@snu.ac.kr
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